HArmonyCa, Marylebone, London

Injectable treatments are revolutionising the way we approach anti-ageing and skin rejuvenation. With so many advanced options available, it can be challenging to navigate which one might be right for you. Two innovative treatments—HArmonyCa and Profhilo Structura—are gaining traction for their ability to restore volume, improve skin quality, and rejuvenate the face. While both are cutting-edge, they work differently and suit different candidates. Let’s dive deeper to understand what sets them apart and which might be best for you.

What is HArmonyCa?

HArmonyCa is a next-generation hybrid dermal filler that combines the benefits of hyaluronic acid (HA) with calcium hydroxyapatite (CaHA). This injectable works not only to restore lost facial volume but also to stimulate collagen production, giving your skin a firmer and more youthful appearance over time.

Hyaluronic acid is well-known for its hydrating and volumising properties, making it a cornerstone ingredient of dermal fillers. The addition of calcium hydroxyapatite in HArmonyCa takes it a step further. As a biostimulator, CaHA encourages the body to produce its own collagen, leading to long-lasting results that extend beyond the immediate effects of the filler.

How it works

HArmonyCa is injected into the subcutaneous layer, beneath the skin, where volume loss occurs. The hyaluronic acid provides an instant plumping and lifting effect, while the calcium hydroxyapatite particles kickstart collagen production. Over time, this dual-action mechanism improves skin elasticity and firmness, giving a natural yet noticeable rejuvenation.

Who is a good candidate?

HArmonyCa is ideal for individuals experiencing early to moderate signs of ageing, such as volume loss in the cheeks or jawline. It is also suitable for those looking to achieve long-term skin tightening while enjoying the immediate benefits of a filler. However, this treatment may not be recommended for those with severe skin laxity, as the lifting effect may not be sufficient.

When will you see results?

You can expect to see instant volumising effects from the hyaluronic acid immediately after treatment. However, the collagen-stimulating benefits of calcium hydroxyapatite take longer, usually becoming apparent after 6–12 weeks. Results can last between 2 and 3 years , depending on your skin type, lifestyle, and metabolism.

What is Profhilo Structura?

Profhilo Structura is a groundbreaking hyaluronic acid injectable gel designed specifically to regenerate subcutaneous fat. Unlike traditional fillers or skin boosters, Profhilo Structura targets the fat layer of the face to address age-related changes in the subcutaneous fat. This is a unique indication, setting it apart as the first product with a proven ability to regenerate fat while offering visible rejuvenation of the overlying skin.

Profhilo Structura combines high and low molecular weight hyaluronic acid using IBSA Derma’s patented NAHYCO technology. This innovative formulation allows the HA to work cohesively, regenerating adipose tissue while also delivering hydrating and skin-firming benefits.

How it works

The unique mechanism of Profhilo Structura is what makes it so exciting. This injectable works in the subcutaneous layer of the face, directly targeting fat loss and tissue atrophy. As we age, the fat pads in our face shrink and sag, leading to hollowing, sagging, and loss of facial volume. Profhilo Structura helps regenerate this lost adipose tissue while improving the skin’s appearance.

By injecting Structura into the subcutaneous fat layer, it restores facial structures, addressing “sinkers” and “saggers.” Sinkers are characterised by hollow, sunken areas caused by adipose tissue depletion, often seen in the lateral cheeks. Saggers, on the other hand, exhibit drooping tissues and fat bulges, where the connective tissue loses its integrity and slides away from the bone structure. Structura works to regenerate these tissues, creating a lifting and firming effect while also benefiting the overlying skin through enhanced hydration and elasticity.

Who is a good candidate?

Profhilo Structura is ideal for individuals who are beginning to experience visible signs of facial sinking or sagging due to subcutaneous fat loss. Unlike traditional fillers, which primarily add volume, Structura focuses on tissue regeneration, offering a more natural, restorative result. This makes it particularly well-suited for those who want to address the underlying causes of ageing rather than simply masking them.

Patients who may benefit from Profhilo Structura include:

  • Individuals with prominent hollowing or a sunken appearance, often seen in the cheeks or other areas of fat loss.
  • Those experiencing drooping tissues and fat bulges, where the skin appears to be sliding away from its structural support.

Profhilo Structura is not designed for those seeking to add significant volume or contour their face. Instead, it’s for patients who want to restore facial structures naturally while improving the quality of the skin above.

When will you see results?

Profhilo Structura offers both short-term and long-term benefits. Patients can expect to see subtle improvements in skin and tissue appearance within the first few weeks. However, the regenerative effects take time as the adipose tissue begins to restore, and full results are typically visible after 6–12 weeks.

Like other Profhilo treatments, Structura also improves skin quality. While its primary action occurs in the subcutaneous fat, the overlying skin benefits from enhanced hydration and elasticity, offering a comprehensive rejuvenation. Results generally last for 9–12 months, and maintenance treatments can help prolong the effects.

What is the difference between HArmonyCa and Profhilo Structura?

HArmonyCa is a hybrid filler that combines hyaluronic acid with calcium hydroxyapatite to provide immediate volume restoration alongside long-term collagen stimulation, making it ideal for patients seeking both lift and improved skin firmness. Profhilo Structura, on the other hand, focuses on regenerating the subcutaneous fat layer to restore the foundational structures of the face while simultaneously enhancing skin quality.

Unlike HArmonyCa, Structura does not aim to directly volumise or contour but instead addresses one of the root causes of age-related sinking and sagging by regenerating fat tissue. Both treatments deliver natural-looking results, but Structura is better suited for patients experiencing structural changes in the face due to fat atrophy, while HArmonyCa is ideal for those needing volumisation with added skin-tightening benefits. Ultimately, the choice depends on the specific ageing concerns and desired outcomes.

Which is right for you?

If your primary concern is loss of structure and facial sinking or sagging caused by fat atrophy, Profhilo Structura is an excellent choice as it targets the subcutaneous fat layer, regenerating lost tissue while subtly improving the overlying skin. It is perfect for those who want to address the foundational changes of ageing with a natural, regenerative approach.

Alternatively, if you’re experiencing volume loss and mild sagging but also want a more immediate lift and contour, HArmonyCa may be the better option, as it combines volumisation with long-term collagen stimulation. For some patients, a combination of the two treatments may be ideal, addressing both skin quality and structure while restoring volume in key areas. A thorough consultation with an experienced practitioner will help identify the best treatment plan tailored to your unique needs and desired results.

If you’d like to learn more about the options, or to understand which may be right for you, click here to enquire or to book a consultation.