Mesotherapy is a needle-based treatment comprised of peptides and amino acids that promises many benefits – from smoothing lines and wrinkles to brightening a tired complexion. But how exactly does it work, and is it worth it? Read on for everything you need to know.

What is mesotherapy?

Originally used to relieve pain, the mesotherapy technique was first developed in 1952 by a French doctor, Michel Pistor. Modern day mesotherapy is minimally invasive and is essentially a series of injections into the middle layer of skin using very fine needles to deliver formulations of vitamins, enzymes, peptides, hyaluronic acid, growth factors, and more. In fact, a typical mesotherapy cocktail contains over 40 active ingredients. Unlike fillers, it doesn’t restore lost volume, and unlike Botox, it doesn’t freeze the muscles, to prevent the formation of lines. Instead, it simply works on improving skin quality and stimulating collagen and elastin production.

Mesotherapy can be used to boost hair growth, rejuvenate, recontour, rehydrate, smooth, and tighten the skin.

What are the skin benefits?

Once the redness has settled, you will notice that your skin is glowing, hydrated, nourished and smooth. Repeat treatments can lead to excellent results in improving skin tone, reducing scarring, and improving skin clarity. Depending on which nutrients are delivered, the treatment can also help with pigmentation and acne scarring. Hyaluronic acid is known to attract and hold on to 1000 times its weight in water, so that can help to restore plumpness in the skin too.

Is it worth it?

I carried out many mesotherapy treatments in the early days of my aesthetics career, but as time has gone on and technology has continued to develop and improve, my preferences have changed. There is one mesotherapy product I am particularly fond of, though. It’s a fairly recent innovation called LightEyes Ultra, a type of mesotherapy formulated especially for the delicate eye area, which is perfect for injecting hydration into the skin to diminish fine lines and crepey skin. The formulation contains Hyaluronic Acid, Ruscus, Vitamin C, antioxidants, and botanical extracts to improve microcirculation, skin elasticity, puffiness, dark circles, and periocular lymphatic drainage whilst protecting against oxidative stress.

The eyes are a particularly tricky area to treat, but LightEyes Ultra is an effective way to tackle common concerns simultaneously, without changing your features, but enhancing and maintaining a fresh look after just one treatment.

The best treatments to try

These days, I usually opt for skin boosters like Profhilo, Viscoderm Hydrobooster and Nucleofill over mesotherapy.

The main difference between skin boosters and mesotherapy mainly lies in the additional components of the mesotherapy cocktails, which can include vitamins, peptides, growth factors, and amino acids. And in contrast to native, non-stabilised HA molecules used in mesotherapy, the cross-linked, softer HA usually used in skin boosters lasts much longer and results in more pronounced clinical improvements in areas where the skin has lost plumpness or lines and wrinkles are more prominent.

Let’s look at the three treatments in more detail…


Profhilo is the first stabilised injectable hyaluronic acid-based product that aims to improve tissue quality whilst treating skin laxity. It is injected at 5 points on each side of the face and spreads evenly throughout the layers of the skin, attracting water along the way. This approach plumps the skin and diminishes fine lines and wrinkles whilst boosting the skin’s radiance and dewiness – delivering a long-lasting serum-type effect, but without the serum. A Profhilo treatment consists of just two treatments spaced four to six weeks apart, and the results will last for approximately six months.

Viscoderm Hydrobooster

Viscoderm Hydrobooster is a stabilised hyaluronic acid injectable which offers dual-action results: intensely hydrating the skin from within whilst also smoothing out and restructuring wrinkles.

This treatment noticeably improves the skin’s elasticity, radiance, and smoothness whilst also eliminating lines and wrinkles for a more youthful appearance. Viscoderm Hydrobooster is particularly useful for those with signs of ageing around mobile areas of the face, such as around the mouth, eyes, and forehead.


Nucleofill differs slightly from other skin boosters, as it’s a bio-stimulant polynucleotide gel rather than a hyaluronic acid formulation. Yet it still does the all-important job of stimulating fibroblasts – the major cells responsible for the production of collagen. Nucleofill directly stimulates specific receptors on the fibroblast cells and produces the healthy collagen that we have in our youth. Nucleofill is fantastic for the more mature age group as it regenerates sagging and dehydrated skin and thickens the tissues.

If you’d like to find out more about skin boosters and the right option for you, click here to enquire or book a consultation.